Journal
CARBOHYDRATE POLYMERS
Volume 273, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118525
Keywords
structure barrier membrane; Hydrothermal method agarpse; Carbonated hydroxyapatite; epsilon-Poly-lysine; Fibrous tissues
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Funding
- Natural Science Foundation of China [21773172]
- Zhejiang Public Welfare Science and Technology Project [LGF21H140006, LGF19H140001]
- Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province [WIBEK181006]
- Public Welfare Science and Technology Plan of Wenzhou [Y2020237]
- [WIUCASQD2019001]
- [WIUCASYJ2020003]
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The asymmetric barrier membrane, made of agarose hydrogel and hollow carbonated hydroxyapatite, enhanced osteoconductive and antibacterial properties, showing good biocompatibility and mechanical strength.
Guided tissue regeneration (GTR) strategies enable periodontal tissue regeneration, generally by providing barrier membranes. However, currently available membranes have limited osteoconductive and antibacterial potential. To address these challenges, we fabricated a new asymmetric barrier membrane. Agarose hydrogel functions as the main body of the barrier membrane. Hollow carbonated hydroxyapatite (CHA) prepared by hydrothermal method, was sedimented in agarose to exhibit an asymmetrical structure. And epsilon-poly-lysine (epsilon-PLL) was chosen as an antimicrobial agent to equip the membrane with long-lasting antibacterial activity. With the increased dose of CHA addition, the barrier membrane shows better biocompatibility, and higher mechanical properties. We demonstrated the osteoconductivity and antibacterial properties of the membrane in vitro and in vivo. In summary, our findings suggest that the barrier membrane has good osteoconductive and antibacterial properties, indicating its potential for periodontal tissue engineering.
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