Journal
CARBOHYDRATE POLYMERS
Volume 272, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118491
Keywords
CD44; Doxorubicin; Drug resistance; Endocytosis; Hyaluronic acid; Nanodelivery system; Theranostic
Categories
Funding
- Ministry of Education - Singapore [MOE-T2EP30120-0016]
- National Research Foundation Singapore
- Singapore Ministry of Education under its Research Center of Excellence initiative to Cancer Science Institute of Singapore
- National University of Singapore
- Spanish Ministry of Economy, Industry, and Competitiveness [SAF2016-76150-R, BFU2017-82421-P]
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Hyaluronic acid-modified nanostructures can enhance the delivery of doxorubicin to cancer cells, overcoming chemoresistance and providing a platform for the co-delivery of genes and drugs.
An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.
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