Journal
CARBOHYDRATE POLYMERS
Volume 278, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118996
Keywords
Chondroitin sulfate zinc; Wound healing; Anti-inflammatory
Categories
Funding
- National Key Research and Development Pro-gram of China [2019YFA0906004]
- National Foundation of Science and Technology [11872200]
- Shenzhen Science and Technology Innovation Committee [JSGG20200225151916021]
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A chondroitin sulfate zinc (CSZn) complex synthesized using ion-exchange method has shown potential in antibacterial and wound healing applications. The CSZn exhibited inhibitory effects on Escherichia coli and Staphylococcus aureus growth and promoted fibroblast growth and wound healing at specific concentrations.
A chondroitin sulfate zinc (CSZn) complex was prepared by an ion-exchange method. The purified product was characterized by energy-dispersive X-ray spectroscopy, high-performance chromatography, elemental analysis, Fourier transform infrared spectroscopy, inductively coupled mass spectrometry, and nuclear magnetic resonance spectroscopy. The CSZn demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus and satisfied MTT cell viability (NIH3T3 fibroblasts) at <= 50 mu g/mL. RT-PCR demonstrated significant promotion by CSZn of fibroblast growth factor beta (beta-FGF), collagen III (COLIII alpha 1), vascular endothelial growth factor (VEGF) and reduction of cytokines IL-6, IL-1 beta & TNF-alpha. An in vivo rat full-thickness wound healing model demonstrated significant wound healing of CSZn relative to controls of saline treatment, zinc chloride treatment and chondroitin treatment. CSZn has demonstrated promising antibacterial and wound healing properties making it deserving of consideration for more advanced wound healing applications.
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