Journal
CARBOHYDRATE POLYMERS
Volume 275, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118779
Keywords
COVID-19; SARS-CoV-2; Angiotensin converting enzyme 2 (ACE2); 3CL protease; Ecklonia kurome Okam; Polysaccharide
Categories
Funding
- National Key Research and Development Program of China
- Ministry of Science and Technology of the People's Republic of China [2019YFC1711-000]
- Key New Drug Creation and Manufacturing Program [2019ZX09735001]
- COVID-19 Emergency Research Project by Zhejiang University [2020XGZX080]
- Shanghai Municipal Science and Technology Commission Major Project
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Research has found that a polysaccharide from seaweed may have inhibitory effects on SARS-CoV-2 infection by targeting key molecules involved in virus infection and replication. This suggests that the polysaccharide could be a potential candidate for an antiviral drug against SARS-CoV-2.
Previous researches suggested that polysaccharides from brown algae had anti-virus activity. We hypothesized that nature polysaccharide from marine plants might have the effect on anti-SARS-CoV-2 activity. By high throughput screening to target 3CLpro enzyme using polysaccharides library, we discover a crude polysaccharide 375 from seaweed Ecklonia kurome blocked 3CLpro enzymatic activity and shows good anti-SARS-CoV-2 infection activity in cell. Further, we show that homogeneous polysaccharide 37502 from the 375 may bind to 3CLpro well and disturb spike protein binding to ACE2 receptor. The structure characterization uncovers that 37502 is alginate. These results imply that the bioactivities of 375 on SARS-CoV-2 may target multiple key molecules implicated in the virus infection and replication. The above results suggest that 375 may be a potential drug candidate against SARS-CoV-2.
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