4.6 Review

Adoptive T-cell immunotherapy in digestive tract malignancies: Current challenges and future perspectives

Related references

Note: Only part of the references are listed.
Article Cell & Tissue Engineering

Effect of adoptive T-cell immunotherapy on immunological parameters and prognosis in patients with advanced pancreatic cancer

Tatsuo Kumai et al.

Summary: The study found that adoptive T-cell immunotherapy (ATI) can alter the immune profile in peripheral blood of pancreatic cancer patients and improve prognosis. Specifically, ATI can decrease CD3+CD4+CD8-T cell frequency, increase CD3+CD4-CD8+T cell frequency, and an increase in CD3+T cells and CD3+TCR gamma delta-T cells is associated with a good prognosis.

CYTOTHERAPY (2021)

Review Medicine, Research & Experimental

Insight into next-generation CAR therapeutics designing CAR T cells to improve clinical outcomes

Emiliano Roselli et al.

Summary: CAR T cell therapy has shown success in hematologic malignancies but faces challenges in solid tumors. Developing novel CAR T cell therapies presents unique challenges, but improved understanding of the tumor microenvironment and resistance mechanisms can help overcome these obstacles.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Review Oncology

Adoptive Cell Therapy in Hepatocellular Carcinoma: Biological Rationale and First Results in Early Phase Clinical Trials

Philippe Rochigneux et al.

Summary: The mortality of hepatocellular carcinoma (HCC) is rapidly increasing worldwide, and immunotherapy involving engineered T cells has shown promising results in clinical trials for combating liver cancer.

CANCERS (2021)

Review Oncology

Checkpoint inhibitors for gastroesophageal cancers: dissecting heterogeneity to better understand their role in first-line and adjuvant therapy

E. C. Smyth et al.

Summary: Anti-PD-1 therapy has become a new standard of care for selected GEA and ESCC patients, providing significant improvement in efficacy. Comparisons of results from different trials demonstrate the pros and cons of various treatment strategies, which will contribute to the development of personalized therapy in the future.

ANNALS OF ONCOLOGY (2021)

Review Gastroenterology & Hepatology

Advances in immunotherapy for hepatocellular carcinoma

Bruno Sangro et al.

Summary: Immunotherapeutic interventions have shown effectiveness in the treatment of hepatocellular carcinoma. Checkpoint inhibitors have demonstrated strong anti-tumor activity, but other immune strategies have not yet shown consistent clinical activity. Advancing treatment to earlier stages, discovering predictive biomarkers, and exploring effective combinatorial approaches are key challenges in HCC immunotherapy.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Oncology

Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead

Kedar Kirtane et al.

Summary: Immune checkpoint inhibitors have significantly changed the standard care for many solid tumor malignancies, but resistance remains common. Adoptive cellular therapy is a rapidly growing form of immunotherapy that shows promise in overcoming resistance mechanisms and has already revolutionized the treatment of hematologic malignancies. The use of ACT in solid tumor malignancies is still in its early stages, with promising therapies under active investigation.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Biochemistry & Molecular Biology

Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma

Jia-qiao Fan et al.

MOLECULAR CANCER (2020)

Review Oncology

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Sarwish Rafiq et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Oncology

Immunotherapy in gastrointestinal cancer: The current scenario and future perspectives

Mohammed Abdul-Latif et al.

CANCER TREATMENT REVIEWS (2020)

Review Oncology

Cellular immunotherapy plus chemotherapy ameliorates survival in gastric cancer patients: a meta-analysis

Guoming Hu et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Medicine, General & Internal

CAR-T Cell Therapy-An Overview of Targets in Gastric Cancer

Dominika Bebnowska et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Immunology

TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

Francesco Manfredi et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

Immunotherapy for advanced hepatocellular carcinoma, where are we?

Li Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Oncology

Allogenic V9V2 T cell as new potential immunotherapy drug for solid tumor: a case study for cholangiocarcinoma

Mohammed Alnaggar et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Oncology

A good start of immunotherapy in esophageal cancer

Qian Zhao et al.

CANCER MEDICINE (2019)

Review Biochemistry & Molecular Biology

Developing neoantigen-targeted T cell-based treatments for solid tumors

Tori N. Yamamoto et al.

NATURE MEDICINE (2019)

Review Public, Environmental & Occupational Health

Safety and Tolerability of Adoptive Cell Therapy in Cancer

Benita Wolf et al.

DRUG SAFETY (2019)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Pathology

Adoptive cellular therapies: the current landscape

Maartje W. Rohaan et al.

VIRCHOWS ARCHIV (2019)

Review Oncology

Chimeric antigen receptor T-cell therapy - assessment and management of toxicities

Sattva S. Neelapu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Oncology

A meta-analysis of adoptive immunotherapy in postoperative hepatocellular carcinoma

Hui Zhao et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2018)

Article Multidisciplinary Sciences

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Joseph A. Fraietta et al.

NATURE (2018)

Review Gastroenterology & Hepatology

Current status of immunotherapy against gastrointestinal cancers and its biomarkers: Perspective for precision immunotherapy

Shoichi Hazama et al.

ANNALS OF GASTROENTEROLOGICAL SURGERY (2018)

Article Biotechnology & Applied Microbiology

Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers

Chengcheng Zhang et al.

MOLECULAR THERAPY (2017)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Eric Tran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

CAR models: next-generation CAR modifications for enhanced T-cell function

Daniel Abate-Daga et al.

MOLECULAR THERAPY-ONCOLYTICS (2016)

Review Multidisciplinary Sciences

Adoptive cell transfer as personalized immunotherapy for human cancer

Steven A. Rosenberg et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Immunogenicity of somatic mutations in human gastrointestinal cancers

Eric Tran et al.

SCIENCE (2015)

Article Gastroenterology & Hepatology

Prolonged overall survival in gastric cancer patients after adoptive immunotherapy

Guo-Qing Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Review Cell Biology

T-cell exhaustion in the tumor microenvironment

Y. Jiang et al.

CELL DEATH & DISEASE (2015)

Editorial Material Oncology

T cell receptor-therapy in HBV-related hepatocellularcarcinoma

Antonio Bertoletti et al.

ONCOIMMUNOLOGY (2015)

Article Medicine, Research & Experimental

Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer

Yoshitaro Shindo et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Article Biotechnology & Applied Microbiology

Postoperative dendritic cell vaccine plus activated T-cell transfer improves the survival of patients with invasive hepatocellular carcinoma

Koichi Shimizu et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Article Oncology

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

Richard A. Morgan et al.

JOURNAL OF IMMUNOTHERAPY (2013)

Article Medicine, Research & Experimental

Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor

Steven C. Katz et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2013)

Article Gastroenterology & Hepatology

Clinical utilization of postoperative dendritic cell vaccine plus activated T-cell transfer in patients with intrahepatic cholangiocarcinoma

Koichi Shimizu et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2012)

Article Biotechnology & Applied Microbiology

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor

J Maher et al.

NATURE BIOTECHNOLOGY (2002)