Journal
CANCER SCIENCE
Volume 113, Issue 3, Pages 926-939Publisher
WILEY
DOI: 10.1111/cas.15265
Keywords
CXC chemokine receptor 4; esophageal squamous cell carcinoma; growth; hypoxia inducible factor-1 alpha; metastasis
Categories
Funding
- National Natural Science Foundation of China [81772619, 82002551]
- Science and Technology Project of Tianjin Municipal Health Commission [KJ20119]
- Bethune Charitable Foundation-Excelsior Surgical Fund [HZB-20190528-11, HZB-20190528-18]
- Clinical Trial Project of Tianjin Medical University [2017kylc006]
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CXCR4, a member of the CXC chemokine receptor family, plays a crucial role in esophageal squamous cell carcinoma (ESCC) by promoting cancer cell proliferation, migration, invasion, and survival. HIF-1α transcriptionally regulates CXCR4 expression, indicating the potential of CXCR4 as a therapeutic target for ESCC.
C-X-C motif chemokine receptor 4 (CXCR4) belongs to the CXC chemokine receptor family, which mediates the metastasis of tumor cells and promotes the malignant development of cancers. However, its biological role and regulatory mechanism in esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we found that CXCR4 expression was associated with lymph node metastasis and a poor prognosis. In vitro and in vivo studies demonstrated that CXCR4 overexpression promoted ESCC cell proliferation, migration, invasion, and survival, whereas silencing CXCR4 induced the opposite effects. Mechanically, HIF-1 alpha transcriptionally regulates CXCR4 expression by binding to a hypoxia response element in its promoter. HIF-1 alpha-induced ESCC cell migration and invasion were reversed by CXCR4 knockdown or treatment with MSX-122, a CXCR4 antagonist. Collectively, these data revealed that the HIF-1 alpha/CXCR4 axis plays key roles in ESCC growth and metastasis and indicated CXCR4 as a potential target for ESCC treatment.
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