Aptamer-based biosensors and application in tumor theranostics

An aptamer is a short oligonucleotide chain that can specifically recognize targeting analytes. Due to its high specificity, low cost, and good biocompatibility, aptamers as the targeting elements of biosensors have been applied widely in non-invasive tumor imaging and treatment in situ to replace traditional methods. In this review, we will summarize recent advances in using aptamer-based biosensors in tumor diagnosis. After a brief introduction of the advantage of aptamers compared with enzyme sensors and immune sensors, the different sensing designs and mechanisms based on 3 signal transduction modes will be reviewed to cover different kinds of analytical methods, including: electrochemistry analysis, colorimetry analysis, and fluorescence analysis. Finally, the prospective advantages of aptamer-based biosensors in tumor theranostics and post-treatment monitoring are also evaluated in this review.

Automated summary

Aptamers, short oligonucleotide chains with high specificity, low cost, and good biocompatibility, have been widely used as targeting elements of biosensors in non-invasive tumor imaging and treatment. This review summarizes recent advances in using aptamer-based biosensors for tumor diagnosis, covering different analytical methods such as electrochemistry analysis, colorimetry analysis, and fluorescence analysis. The potential advantages of aptamer-based biosensors in tumor theranostics and post-treatment monitoring are also discussed.