Journal
CANCER LETTERS
Volume 522, Issue -, Pages 14-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.09.008
Keywords
Glioma; Molecular pathology; Extent of resection; Chinese glioma genome atlas; Survival
Categories
Funding
- National Natural Science Foundation of China [82072786]
- Beijing Medical Development Project [JYY2019-5]
Ask authors/readers for more resources
The study found that extensive resection may not always prolong survival in patients with gliomas. In addition to clinical characteristics, molecular pathology also positively impacts survival in gliomas. Neurosurgeons may benefit from considering both factors when planning surgery for glioma patients in the future.
Surgeons have considered extending the resection margins for better outcomes in gliomas, but have not considered molecular pathology. We investigated the impact of molecular pathology on the surgical benefit in gliomas. Herein, we collected the clinical and pathological information of 449 patients with glioma from the Chinese Glioma Genome Atlas database, and enrolled those who underwent surgical resection. We measured the impact of the extent of resection on survival time in subgroups classified by clinical characteristics. We found that gross total resection (GTR) was associated with longer survival times in the entire cohort, and each of the three molecular subtypes. Even after age stratification, there was no survival benefit from GTR in those with a Karnofsky performance score (KPS) 80. In patients aged 45 years with a KPS 80. In conclusion, extensive resection does not always prolong survival in patients with glioma. Along with clinical characteristics, molecular pathology positively impacts survival in gliomas. Neurosurgeons may consider our findings when planning surgery in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available