Noncoding RNAs in triple negative breast cancer: Mechanisms for chemoresistance

Triple-negative breast cancer (TNBC) is the most aggressive subtype among breast cancers with high recurrence and this condition is partly due to chemoresistance. Therefore, fully understanding the mechanism of TNBCresistance is the key to overcoming chemoresistance, which will be an effective strategy for TNBC therapy. Various potential mechanisms involved in the chemoresistance of TNBC have been investigated and indicated that noncoding RNAs (ncRNAs) especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) take part in most TNBC resistance. The ncRNA-induced chemoresistance process is involved in the alteration of many activities. here, we mainly summarize the mechanisms of ncRNAs in the chemoresistance of TNBC and discuss the potential clinical application of ncRNAs in the treatment of TNBC, indicating that targeting ncRNAs might be a promising strategy for resensitization to chemotherapies.

Automated summary

Triple-negative breast cancer (TNBC) is the most aggressive subtype among breast cancers, with high recurrence partly due to chemoresistance. Studies have shown that noncoding RNAs, especially miRNAs, lncRNAs, and circRNAs, play a role in TNBC resistance, suggesting that targeting ncRNAs may be a promising strategy to overcome chemoresistance.