Journal
CANCER LETTERS
Volume 527, Issue -, Pages 164-173Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.12.019
Keywords
Hippo-YAP; TAZ signaling; Coactivator; Context-dependent; Transriptional regulation; Cancer
Categories
Funding
- Fundamental Research Funds for the Central Universities [20ykzd02]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515110285]
- National Natural Science Foundation of China [32000679, 82072901]
- Shenzhen Science and Technology Innovation Commission [JCYJ20210324120409026]
- Guangdong Provincial Key Laboratory of Digestive Cancer Research [2021B1212040006]
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This article provides an overview of the core components and upstream regulators of Hippo-YAP/TAZ signaling in mammals, and systematically summarizes the identified transcription factors or partners responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
As the downstream effectors of Hippo pathway, YAP/TAZ are identified to participate in organ growth, regeneration and tumorigenesis. However, owing to lack of a DNA-binding domain, YAP/TAZ usually act as coactivators and cooperate with other transcription factors or partners to mediate their transcriptional outputs. In this article, we first present an overview of the core components and the upstream regulators of Hippo-YAP/TAZ signaling in mammals, and then systematically summarize the identified transcription factors or partners that are responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
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