Journal
CANCER LETTERS
Volume 521, Issue -, Pages 82-87Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.08.036
Keywords
Circulating microbiome DNA; Bacteria; Carcinogenesis; Diagnostic biomarkers
Categories
Funding
- Beijing Municipal Natural Science Foundation [7212122]
- Peking University People's Hospital Scientific Research Development Funds [RDH 2020-10]
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Dysbiosis of the human microbiome has been linked to various cancers, with differential microbiome composition potentially serving as novel biomarkers for cancer detection and immunotherapy success. Furthermore, circulating microbiome DNA alterations have shown promise as noninvasive biomarkers for cancer detection, with distinct bacterial DNA able to differentiate cancer patients from healthy individuals.
Dysbiosis of the human microbiome has long been reported to be closely associated with various cancers. Accumulating studies have shown that microbial dysbiosis can accelerate tumorigenesis through tumorpromoting inflammation, DNA damage, and inducing immune evasion. Differential composition of microbiome could be novel biomarkers for cancer detection or biomarkers of successful immunotherapy. More importantly, emerging evidence demonstrates that alterations of circulating microbiome DNA (cmDNA) could serve as promising noninvasive biomarkers for cancer detection. It has been reported that distinct circulating bacterial DNA could distinguish prostate cancer, lung cancer, and melanoma patients from healthy populations. Therefore, in this review, we summarized current literature on microbial biomarkers for cancer detection and unraveled the potential of cmDNA as a promising cancer detection tool.
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