Age-Related Disease Risks in Younger versus Older B-Cell Non-Hodgkin's Lymphoma Survivors

Background: Younger cancer survivors may develop age-related diseases due to the cancer treatment that they undergo. The aim of this population-based study is to estimate incidence of age-related diseases besides cardiovascular disease among younger versus older B-cell non-Hodgkin's lymphoma (B-NHL) survivors compared with their respective general population cohorts. Methods: Survivors of B-NHL were diagnosed between 1997 and 2015 from the Utah Cancer Registry. Using the Utah Population Database, up to 5 cancer-free individuals from the general population were matched with a B-NHL survivor on sex, birth year, and state of birth. Hazard ratios (HR) for age-related disease outcomes, which were identified from medical records and statewide health care facility data, were estimated using Cox Proportional Hazardsmodels for B- NHL survivors diagnosed at <65 years versus >= 65 years at least 5 years since B-NHL diagnosis. Results: Comparing 2,129 B-NHL survivors with 8,969 individuals from the general population, younger B-NHL survivors had higher relative risks of acute renal failure [HR, 2.24; 99% confidence interval (CI), 1.48-339; P-heterogeneity = 0.017), pneumonia (HR, 2.42; 99% Ci, 1.68-3.49; P-heterogeneity = 0.055), and nutritional deficiencies (HR, 2.08; 99% CI, 1.48-2.92; P-heterogeneity = 0.051) >= 5 years after cancer diagnosis. Conclusion: Younger B-NHL survivors had higher relative risks of acute renal failure, pneumonia, and nutritional deficiencies than older B-NHI, survivors compared with their respective general population cohorts, >= 5 years after cancer diagnosis.

Automated summary

The study findings indicated that younger B-NHL survivors had higher relative risks of acute renal failure, pneumonia, and nutritional deficiencies compared with their respective general population cohorts, >= 5 years after cancer diagnosis.