Detection accuracy of the Cobas HPV assay for high-risk HPV in head and neck FNA biopsy specimens

Article Medical Laboratory Technology

Liquid phase human papillomavirus genotype analysis of aspirated metastatic head and neck squamous cell carcinoma: Fine needle aspiration supernatant is a rich source of tumorDNAthat can increase the diagnostic yield

Yansheng Hao et al.

Summary: The study aimed to determine if the residual supernatant portion of FNA could be used to accurately determine the HPV status in patients with HPV-related head and neck squamous cell carcinoma.

DIAGNOSTIC CYTOPATHOLOGY (2021)

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Article Oncology

Optimizing TreatmentDe-Escalationin Head and Neck Cancer: Current and Future Perspectives

Ari J. Rosenberg et al.

Summary: The treatment of locoregionally advanced head and neck squamous cell carcinoma typically involves a multidisciplinary approach, but there has been recent discussion on de-escalation strategies. Research has focused on how to minimize toxicity while maintaining good treatment outcomes. While there are ongoing de-escalation trials, there is still controversy surrounding patient selection and de-escalation strategies.

ONCOLOGIST (2021)

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Article

p16 immunostaining in fine-needle aspirations of the head and neck: determining the optimal positivity threshold in HPV-related squamous cell cancer

Qian Wang et al.

Journal of the American Society of Cytopathology (2021)

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Article Oncology

Quantitative assessment of p16 expression in FNA specimens from head and neck squamous cell carcinoma and correlation with HPV status

Rita Abi-Raad et al.

Summary: At least 40% of p16 expression in tumor clusters may be appropriate threshold for p16 positivity in cytology CB specimens. HPV by PCR on needle rinse can serve as a substitute for p16 expression in surgical specimens, with 88% sensitivity and 100% specificity.

CANCER CYTOPATHOLOGY (2021)

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Article Oncology

Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002)

Sue S. Yom et al.

Summary: Reducing radiation treatment dose in patients with good-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma (OPSCC) could potentially improve the quality of life. The study showed that reducing radiation dose could achieve disease control and survival rates equivalent to standard chemoradiation.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Review Oncology

Proton Therapy for HPV-Associated Oropharyngeal Cancers of the Head and Neck: a De-Intensification Strategy

Nicolette Taku et al.

Summary: The rise in HPV-associated OPC, diagnosed at a young age with a good prognosis, has led to the need for treatment techniques like IMPT, which reduce side effects. Preclinical studies show that HPV-positive squamous cell carcinoma is more sensitive to proton radiation. Retrospective studies suggest that IMPT has lower rates of side effects compared to intensity-modulated photon radiotherapy. Two phase III trials are expected to provide evidence on the effectiveness of IMPT for these patients.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

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Article Oncology