Journal
CANCER CELL
Volume 39, Issue 11, Pages 1450-1452Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2021.09.004
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Funding
- Intramural Research Program of the Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH)
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The study identified an immunosuppressive mechanism in prostate cancer bone metastasis, primarily involving infiltration of M2 macrophages and T cell exhaustion mediated by the CCL20-CCR6 axis.
Therapeutic options for metastatic prostate cancer patients are currently limited. In this issue of Cancer Cell , Kfoury et al. characterized the tumor and immune compartments of prostate cancer bone metastasis, revealing a mechanism of immunosuppression that involves infiltration with M2 macrophages and T cell exhaustion mediated by the CCL20-CCR6 axis.
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