Journal
CANCER CELL
Volume 39, Issue 12, Pages 1578-+Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2021.09.010
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Funding
- Beijing Municipal Science and Technology Commission [Z201100005320014]
- National Key R&D Program of China [2020YFA0803300, 2018YFC1312101]
- National Natural Science Foundation of China [82030089, 81988101, 91942307, 31991171]
- CAMS Innovation Fund for Medical Sciences [2016-I2M-1-001, 2017-I2M-3004, 2019-I2M-1-003]
- Non-profit Central Research Institute Fund of CAMS [2019PT310027]
- Capital's Funds for Health Improvement and Research [CFH2018-4-4024]
- Boya Postdoctoral Foundation of Peking University
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The study indicates that high levels of baseline CXCL13(+) T cells are associated with effective responses to combination therapy in triple-negative breast cancer patients. These cells increase following combination therapy but decrease after monotherapy, highlighting their importance in predicting treatment outcomes.
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with advanced TNBC treated with paclitaxel or its combination with the anti-PD-L1 atezolizumab. We demonstrate that high levels of baseline CXCL13(+) T cells are linked to the proinflammatory features of macrophages and can predict effective responses to the combination therapy. In responsive patients, lymphoid tissue inducer (LTi) cells, follicular B (Bfoc) cells, CXCL13(+) T cells, and conventional type 1 dendritic cells (cDC1) concertedly increase following the combination therapy, but instead decrease after paclitaxel monotherapy. Our data highlight the importance of CXCL13(+) T cells in effective responses to anti-PD-L1 therapies and suggest that their reduction by paclitaxel regimen may compromise the clinical outcomes of accompanying atezolizumab for TNBC treatment.
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