Journal
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
Volume -, Issue -, Pages -Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cbr.2021.0336
Keywords
bioinformatics; drug sensitivity; kidney renal clear cell carcinoma; plexins
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The study aimed to identify dysregulated plexins and investigate their roles in KIRC through an integrated bioinformatics approach. The results revealed that PLXNA1/B3 were independent prognostic factors in KIRC, and may promote ccRCC progression through cancer-related signaling pathways, tumor immunity, and angiogenesis. Drug sensitivity analysis suggested that vemurafenib was a potential drug for PLXNA1/B3.
Aims: This study sets out to identify dysregulated plexins and investigate their roles in KIRC through an integrated bioinformatics approach.Methods: RNA-sequencing data and clinicopathological information of KIRC, extracted from The Cancer Genome Atlas (TCGA) database, were used to perform comprehensive bioinformatics analysis.Results: Almost all plexin gene family members were dysregulated in KIRC. Univariate and multivariate Cox regression analyses revealed that PLXNA1/B3 were independent prognostic factors of overall survival in patients with KIRC. Mechanically, PLXNA1/B3 may promote ccRCC progression through several cancer-related signaling pathways, tumor immunity, and angiogenesis. Drug sensitivity analysis suggested that vemurafenib was the potential drug for PLXNA1/B3.Conclusion: Herein, we found that PLXNA1/B3 were independent prognostic factors, making them attractive new targets for KIRC treatment.
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