Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 100, Issue 3, Pages 217-223Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjc-2021-0197
Keywords
copper oxide; flow chemistry; A3-coupling; propargylamine; microwave; low loading
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant program
- Canada Foundation for Innovation (CFI)
- Canada Research Chairs (CRC)
- Fonds de Recherche du Quebec-Nature et Technologies (FRQNT) Equipe program
- Centre for Green Chemistry and Catalysis (CGCC)
- NSERC-Collaborative Research and Training Experience (CREATE) in Green Chemistry
- NSERC-CREATE Program in Continuous Flow Science
- McGill University
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This study investigates the synthesis of propargylamine using Cu(I) catalysts under solvent-free and low loading conditions. The catalytic activity of well-defined Cu2O microcrystals with different structures is also compared. It is found that ultra-low loading conditions with Cu(I) salts as catalysts can achieve high turnover frequencies. In situ generation of low dose Cu(I) ions enables excellent catalytic activities within minutes and multiple recycling in a flow reactor.
Cu(I) catalysts were studied for the synthesis of a propargylamine via A(3)-coupling of aldehyde, amine, and alkyne, under solvent-free and low loading conditions, using batch microwave or flow thermal heating. We explored ultra-low loading conditions with Cu(I) salts as fast and active catalysts featuring turnover frequencies (TOFs) above 10(5) h(-1). Well-defined octahedral and cubic Cu2O microcrystals were also successfully applied and compared with this reaction. Both types of microcrystals exhibited excellent catalytic activities within minutes, via in situ generation of low dose of Cu(I) ions within the reaction medium, to achieve TON beyond 2000 and recycling up to 10 times in a flow reactor. The study of the catalytic system demonstrated that the activity was surface-structure dependent and allowed for the design of low Cu contamination A(3)-coupling systems, affording a product at the decigram scale, with Cu contamination below FDA recommendations for drug synthesis, without the need for a purification procedure.
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