Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease

A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.

Automated summary

The study found that rats with rotenone-induced parkinsonism exhibited dysfunction in the antioxidant system, leading to inhibition of the majority of antioxidant enzymes in the brain and blood serum, which may be attributed to the decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes significantly contribute to neuronal degeneration in the cerebral cortex and striatum, as well as motor disorders in experimental animals.