Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 172, Issue 2, Pages 133-136Publisher
SPRINGER
DOI: 10.1007/s10517-021-05349-3
Keywords
toxic hepatitis; liver microsomes; cytochrome P-450; nitric oxide system; sesquiterpene lactones
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After a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg) in rats with toxic CCl4-induced hepatitis, significant changes in enzyme activities of phases I and II of xenobiotic biotransformation and parameters of NO metabolism were observed in liver microsomes, suggesting that sesquiterpene lactones can stimulate the recovery of the cytochrome P-450 system and NOergic system.
We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.
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