4.2 Article

Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

Journal

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 172, Issue 2, Pages 133-136

Publisher

SPRINGER
DOI: 10.1007/s10517-021-05349-3

Keywords

toxic hepatitis; liver microsomes; cytochrome P-450; nitric oxide system; sesquiterpene lactones

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After a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg) in rats with toxic CCl4-induced hepatitis, significant changes in enzyme activities of phases I and II of xenobiotic biotransformation and parameters of NO metabolism were observed in liver microsomes, suggesting that sesquiterpene lactones can stimulate the recovery of the cytochrome P-450 system and NOergic system.
We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.

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