4.6 Article

New insights into change of lens proteins' stability with ageing under physiological conditions

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Cataract-causing mutations L45P and Y46D promote γC-crystallin aggregation by disturbing hydrogen bonds network in the second Greek key motif

Chenxi Fu et al.

Summary: Congenital cataracts caused by genetic disorders are the primary cause of child blindness across the globe. This study investigated two mutations of gamma C-crystallin in Chinese families with nuclear congenital cataracts, revealing that these mutations destabilized the protein and increased aggregation propensity under environmental stress.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

beta B2 W151R mutant is prone to degradation, aggregation and exposes the hydrophobic side chains in the fourth Greek Key motif

Jingjie Xu et al.

Summary: Congenital cataract is a major cause of blindness in children globally. A novel beta B2 mutation W151R was found to be prone to aggregation due to low solubility and poor structural stability, but the negative effect of the mutation was reversed by administration of lanosterol.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Article Engineering, Environmental

Achieved deep-dewatering of dredged sediments by Fe(II) activating persulfate pretreatment: Filtrating performance and mechanistic insights

Yifu Li et al.

Summary: The study achieved deep-dewatering of dredged sediments using Fe(II)/Persulfate pretreatment for the first time, which was found to break down EPS matrix, alter proteic conformation, and strengthen hydrophobicity, resulting in enhanced dewaterability of sediments.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Biochemistry & Molecular Biology

Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures

Li-Dan Hu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Article Chemistry, Multidisciplinary

Lanosterol Disrupts Aggregation of Human γD-Crystallin by Binding to the Hydrophobic Dimerization Interface

Hongsuk Kang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Biochemistry & Molecular Biology

Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding

Wei-Jie Zhao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Review Public, Environmental & Occupational Health

Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis

Seth R. Flaxman et al.

LANCET GLOBAL HEALTH (2017)

Review Biochemistry & Molecular Biology

The etiology of human age-related cataract. Proteins don't last forever

Roger J. W. Truscott et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)

Editorial Material Multidisciplinary Sciences

OPHTHALMOLOGY Cataracts dissolved

J. Fielding Hejtmancik

NATURE (2015)

Article Multidisciplinary Sciences

Lanosterol reverses protein aggregation in cataracts

Ling Zhao et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Lens Crystallin Modifications and Cataract in Transgenic Mice Overexpressing Acylpeptide Hydrolase

Puttur Santhoshkumar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Lens β-crystallins: The role of deamidation and related modifications in aging and cataract

Kirsten J. Lampi et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2014)

Article Pharmacology & Pharmacy

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Alexander Mazein et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Ophthalmology

Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?

Roger J. W. Truscott et al.

EXPERIMENTAL EYE RESEARCH (2012)

Review Biology

Biological glass: structural determinants of eye lens transparency

Steven Bassnett et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

Article Biochemistry & Molecular Biology

Age-dependent protein modifications and declining proteasome activity in the human lens

G Viteri et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)

Review Biochemistry & Molecular Biology

Ageing and vision: structure, stability and function of lens crystallins

H Bloemendal et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

S-methylated cysteines in human lens γS-crystallins

VN Lapko et al.

BIOCHEMISTRY (2002)