Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 196, Issue 4, Pages 1086-1095Publisher
WILEY
DOI: 10.1111/bjh.17977
Keywords
immune thrombocytopenia; anti-HBc(+); platelets; efficacy
Categories
Funding
- National Natural Science Foundation of China [81100348, 81770114, 81973994, 81900121, 81770133, 81900124]
- clinical research and cultivation project of Shandong University [2020SDUCRCC009]
Ask authors/readers for more resources
This study investigated the impact of previous HBV exposure on disease severity and treatment response in ITP patients. The results suggest that anti-HBc positivity may be a predictor for poor response to ITP-specific treatments and is associated with increased disease severity and longer hospitalization.
The association of previous hepatitis B virus (HBV) exposure [hepatitis B surface antigen (HBsAg) negative, hepatitis B core antibody (anti-HBc/HBcAb) positive] with disease severity and decision on treatment option in primary immune thrombocytopenia (ITP) patients remains unclear. Data from 725 patients diagnosed with ITP were analyzed to elucidate the association between anti-HBc serological status and disease severity. Data from a published prospective study [high-dose dexamethasone (HD-DXM), HD-DXM plus recombinant human thrombopoietin, NCT01734044] and two retrospective studies (standard-dose and low-dose rituximab) were rearranged to evaluate the impact of anti-HBc serological status on the response and outcome to ITP-specific treatments and the risk of HBV reactivation related to these treatments. The prevalence of HBsAg(-)HBcAb(+) and HBsAg(-)HBcAb(-) in ITP patients was 51 center dot 03% and 48 center dot 97% respectively. Compared to the HBsAg(-)HBcAb(-) group, patients in the HBsAg(-)HBcAb(+) group had lower platelet count, higher bleeding score, and longer hospitalization (P = 0 center dot 002, 0 center dot 033, and 0 center dot 008 respectively). Moreover, the initial complete response rate of HBsAg(-)HBcAb(+) patients was lower than that of HBsAg(-)HBcAb(-) patients (45 center dot 2% vs 59 center dot 8%, P = 0 center dot 027). In conclusion, previous HBV exposure was correlated with disease severity and hospitalization in ITP patients. Anti-HBc positivity may be considered as a predictor for poor response to ITP-specific treatments.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available