Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 191, Issue 1, Pages 115-124Publisher
SPRINGER
DOI: 10.1007/s10549-021-06419-w
Keywords
Breast cancer; Lymphedema; MRI; MR relaxometry; Adipose tissue; Edema
Categories
Funding
- Lipedema Foundation (LF) Postdoctoral Research Fellowship
- American Heart Association (AHA) [18CDA34110297]
- AHA [19IPLOI34760518]
- NIH [1S10OD021771-01]
- National Center for Advancing Translational Sciences (NCATS) Clinical Translational Science Award (CTSA) Program [5UL1TR002243-03]
- NCATS/NIH [UL1 TR000445]
- LF Collaborative Grant [12]
- [NIH/NINR 1R01NR015079]
- [NIH/NHLBI 1R01HL155523]
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This study found that adiposity quantified by MRI is elevated in the affected upper extremity of women with BCRL, potentially serving as a surrogate marker for the onset or severity of the condition.
Purpose Breast cancer treatment-related lymphedema (BCRL) is a common co-morbidity of breast cancer therapies, yet factors that contribute to BCRL progression remain incompletely characterized. We investigated whether magnetic resonance imaging (MRI) measures of subcutaneous adipose tissue were uniquely elevated in women with BCRL. Methods MRI at 3.0 T of upper extremity and torso anatomy, fat and muscle tissue composition, and T-2 relaxometry were applied in left and right axillae of healthy control (n = 24) and symptomatic BCRL (n = 22) participants to test the primary hypothesis that fat-to-muscle volume fraction is elevated in symptomatic BCRL relative to healthy participants, and the secondary hypothesis that fat-to-muscle volume fraction is correlated with MR relaxometry of affected tissues and BCRL stage (significance criterion: two-sided p < 0.05). Results Fat-to-muscle volume fraction in healthy participants was symmetric in the right and left sides (p = 0.51); in BCRL participants matched for age, sex, and BMI, fat-to-muscle volume fraction was elevated on the affected side (fraction = 0.732 +/- 0.184) versus right and left side in controls (fraction = 0.545 +/- 0.221, p < 0.001). Fat-to-muscle volume fraction directly correlated with muscle T-2 (p = 0.046) and increased with increasing level of BCRL stage (p = 0.041). Conclusion Adiposity quantified by MRI is elevated in the affected upper extremity of women with BCRL and may provide a surrogate marker of condition onset or severity.
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