Journal
BREAST
Volume 60, Issue -, Pages 192-198Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.breast.2021.10.006
Keywords
Breast reconstruction; Immediate direct-to-implant; Acellular dermal matrix; Complications; Reconstructive failure; Risk factors
Categories
Funding
- Danish Cancer Society
- Herlev and Gentofte Hospital research foundation
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Immediate direct-to-implant breast reconstruction with acellular dermal matrix (ADM) is a popular method, but the use of ADM remains controversial. This study investigated complications and risk factors in this procedure, finding a 34% complication rate within 6 months and a 13% explantation rate. Proper patient selection is crucial in minimizing complications.
Objective: Immediate direct-to-implant breast reconstruction with acellular dermal matrix (ADM) is the method of choice for many plastic surgeons and patients, but the use of ADM remains a controversial subject in the literature. This study aimed to investigate complications, reconstructive failure and possible risk factors in directto-implant breast reconstruction with ADM (primarily StratticeTM). Methods: We retrospectively examined all patients undergoing immediate direct-to-implant breast reconstruction with ADM, during a five-year period (2014-2019) at a university clinic. Study outcomes were all complications and explantations. Complications were stratified within and after 6 months postoperatively and subcategorized by type of intervention. Explantations were subcategorized into loss of implant or salvage with immediate insertion of a tissue expander, the same or a new implant. Results: We included 154 patients and 232 breasts. Complications within 6 months per patient included hematoma (4%), seroma (8%), infection (9%), necrosis, wound dehiscence and delayed wound healing (19%). The total complication rate per patient was 34%. Explantation occurred in 20 patients (13%) of which 9 (6% of all) had implant loss. Preoperative radiotherapy was a significant predictor of explantation (adjusted OR 4.9, 95% confidence interval (CI), 1.0-23.5; p = 0.045), and smoking was also associated with risk of explantation, although only borderline significant (adjusted OR 4.0, 95% CI, 1.0-15.8; p = 0.050). Conclusion: This study demonstrates acceptable rates of re-operations and implant loss compared to other studies but highlights the importance of proper patient selection with regards to risk factors to minimize complications. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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