Journal
BRAIN PATHOLOGY
Volume 32, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/bpa.13030
Keywords
claustrum; corticobasal degeneration; digital pathology; progressive supranuclear palsy; tauopathy
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Funding
- Western University Pathology Internal Funds for Academic Development (PIFAD)
- Western University Dean's Undergraduate Research Opportunity Program (DUROP)
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Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) involves interpreting tau morphology through extensive brain sampling. Subcortical tau burden can effectively differentiate between PSP and CBD, with the tau pallido-claustral ratio showing promise as a diagnostic indicator for these conditions.
Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.
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