Alterations of dynamic functional connectivity between visual and executive-control networks in schizophrenia

Schizophrenia is a chronic mental disorder characterized by continuous or relapsing episodes of psychosis. While previous studies have detected functional network connectivity alterations in patients with schizophrenia, and most have focused on static functional connectivity. However, brain activity is believed to change dynamically over time. Therefore, we computed dynamic functional network connectivity using the sliding window method in 38 patients with schizophrenia and 31 healthy controls. We found that patients with schizophrenia exhibited higher occurrences in the weakly and sparsely connected state (state 3) than healthy controls, positively correlated with negative symptoms. In addition, patients exhibited fewer occurrences in a strongly connected state (state 4) than healthy controls. Lastly, the dynamic functional network connectivity between the right executive-control network and the medial visual network was decreased in schizophrenia patients compared to healthy controls. Our results further prove that brain activity is dynamic, and that alterations of dynamic functional network connectivity features might be a fundamental neural mechanism in schizophrenia.

Automated summary

In this study, we computed dynamic functional network connectivity using the sliding window method in patients with schizophrenia and healthy controls. Our results showed that patients with schizophrenia had higher occurrences in the weakly connected state, positively correlated with negative symptoms. They also had fewer occurrences in the strongly connected state compared to healthy controls. Additionally, the dynamic functional network connectivity between certain brain networks was decreased in schizophrenia patients.