Journal
BRAIN IMAGING AND BEHAVIOR
Volume 16, Issue 3, Pages 1451-1464Publisher
SPRINGER
DOI: 10.1007/s11682-021-00589-3
Keywords
Meta-analysis; MRI; Executive function; Central executive network; Schizophrenia
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Funding
- Suffolk University Psychology Department
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This study found a positive association between structural and functional neuroimaging and executive function, with a lower association found in the control group for structural neuroimaging. There were no significant differences in the strength of the brain-behavior relationship in both schizophrenia and control groups.
This meta-analysis evaluated the extent to which executive function can be understood with structural and functional magnetic resonance imaging. Studies included structural in schizophrenia (k = 8; n = 241) and healthy controls (k = 12; n = 1660), and functional in schizophrenia (k = 4; n = 104) and healthy controls (k = 12; n = 712). Results revealed a positive association in the brain behavior relationship when pooled across schizophrenia and control samples for structural (pr = 0.27) and functional (pr = 0.29) modalities. Subgroup analyses revealed no significant difference for functional neuroimaging (pr = .43, 95%CI = -.08-.77, p = .088) but with structural neuroimaging (pr = .37, 95%CI = -.08-.69, p = .015) the association to executive functions is lower in the control group. Subgroup analyses also revealed no significant differences in the strength of the brain-behavior relationship in the schizophrenia group (pr = .59, 95%CI = .58-.61, p = .881) or the control group (pr = 0.19, 95%CI = 0.18-0.19, p = 0.920), suggesting concordance.
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