4.7 Article

Real-world experience of assessing antibodies against the N-methyl-D-aspartate receptor (NMDAR-IgG) in psychiatric patients. A retrospective single-centre study

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Thomas A. Pollak et al.

Summary: Neuronal autoantibodies, including NMDAR antibodies, can be detected in a subgroup of CHR subjects at equal rates to controls. These antibodies are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function. Serum status and titre of NMDAR antibodies are related to poorer levels of functioning and the presence of a neuronal autoantibody is associated with larger amygdala volumes.

MOLECULAR PSYCHIATRY (2021)

Article Clinical Neurology

Comparison of N-methyl-d-aspartate receptor antibody assays using live or fixed substrates

Anais Thouin et al.

Summary: The study compared different detection methods for NMDAR-Ab encephalitis and found that CSF results were generally accurate, but there was variability in sensitivity for serum results. When CSF is unavailable, negative serum C-CBA results may require retesting with a more sensitive in-house assay.

JOURNAL OF NEUROLOGY (2021)

Review Behavioral Sciences

Cycloid psychosis as a psychiatric expression of anti-NMDAR encephalitis. A systematic review of case reports accomplished with the authors' cooperation

Eloi Gine Serven et al.

Summary: Research has found that the cycloid psychosis (CP) phenotype is a common clinical presentation of psychiatric symptoms in patients with anti-NMDA receptor encephalitis (NMDARE), characterized by acute psychotic episodes with a sudden onset and a fluctuating clinical pattern, including confusion, delusions, hallucinations, motility disturbances, and mood oscillations. Patients who display the CP phenotype during their first psychotic episode should undergo cerebrospinal fluid analysis to rule out a possible diagnosis of autoimmune encephalitis.

BRAIN AND BEHAVIOR (2021)

Article Clinical Neurology

Clinical, Neuroimmunologic, and CSF Investigations in First Episode Psychosis

Mar Guasp et al.

Summary: The study found that NMDAR antibodies were not common in FEP patients without anti-NMDAR encephalitis, and the warning signs and criteria for autoimmune psychosis had limited utility when neurological symptoms were absent or paraclinical tests were normal.

NEUROLOGY (2021)

Article Psychiatry

Neural Autoantibodies in Cerebrospinal Fluid and Serum in Clinical High Risk for Psychosis, First-Episode Psychosis, and Healthy Volunteers

Christian G. Bien et al.

Summary: The study revealed that detecting neural autoantibodies in patients with psychotic disorders is rare, and emphasized the importance of CSF analysis for reliably detecting these autoantibodies.

FRONTIERS IN PSYCHIATRY (2021)

Article Neurosciences

Relationship Between Serum NMDA Receptor Antibodies and Response to Antipsychotic Treatment in First-Episode Psychosis

Thomas A. Pollak et al.

Summary: In patients with first-episode psychosis, the presence of NMDAR antibodies does not indicate a need for immunotherapy instead of antipsychotic medications. Further studies are needed to determine the proportion of FEP patients who are NMDAR antibody positive and may benefit from immunotherapy based on coexisting cerebrospinal fluid inflammatory changes or other paraclinical evidence.

BIOLOGICAL PSYCHIATRY (2021)

Article Psychiatry

Influence of methodological and patient factors on serum NMDAR IgG antibody detection in psychotic disorders: a meta-analysis of cross-sectional and case-control studies

Alexis E. Cullen et al.

Summary: The study found that higher estimates of NMDAR IgG antibody prevalence were obtained using the live cell-based assay, and seropositivity was more common in patients with psychosis than in controls when this method was used. The effects of illness stage and study quality on heterogeneity were inconsistent, providing clear recommendations for clinicians and researchers on interpreting these findings.

LANCET PSYCHIATRY (2021)

Article Clinical Neurology

Clinical features of seronegative, but CSF antibody-positive, anti-NMDA receptor encephalitis

Mar Guasp et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

Article Clinical Neurology

The Psychiatric Phenotype of Anti-NMDA Receptor Encephalitis

Lucy L. Gibson et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2019)

Article Multidisciplinary Sciences

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

Julie Jezequel et al.

NATURE COMMUNICATIONS (2017)

Article Clinical Neurology

Clinical relevance of serum antibodies to extracellular N-methyl-D-aspartate receptor epitopes

Michael S. Zandi et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2015)

Article Clinical Neurology

Seroprevalence of Autoantibodies against Brain Antigens in Health and Disease

Liane Dahm et al.

ANNALS OF NEUROLOGY (2014)

Article Psychiatry

Serum IgG Antibodies Against the NR1 Subunit of the NMDA Receptor Not Detected in Schizophrenia

Joseph C. Masdeu et al.

AMERICAN JOURNAL OF PSYCHIATRY (2012)

Article Clinical Neurology

Cognitive deficits following anti-NMDA receptor encephalitis

Carsten Finke et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)