Journal
BONE
Volume 151, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2021.116032
Keywords
Bone Mechanobiology; Multiscale modeling; Computer simulations; Scaffold design; Implant design; Mechano-driven bone regeneration
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Funding
- European Union's Horizon 2020 research and innovation programme under the Marie SkodowskaCurie grant [722535]
- Spanish Ministry of Economy and Competitiveness (Spain) [DPI 2017-84780-C2-1-R, RTI2018094494BC21]
- European Union (European Regional Development Fund)
- Marie Curie Actions (MSCA) [722535] Funding Source: Marie Curie Actions (MSCA)
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The mechanical environment plays a crucial role in regulating the properties and adaptive behavior of bone tissue. Changes in mechanical environment can induce significant effects on bone response, implant design, and scaffold-driven bone regeneration.
Mechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and our own organs. This regulatory role is especially relevant for bones, given their importance as load transmitting elements that allow the movement of our body as well as the protection of vital organs from load impacts. Therefore bone, as living tissue, is continuously adapting its properties, shape and repairing itself, being the mechanical loads one of the main regulatory stimuli that modulate this adaptive behavior. Here we review some key results of bone mechanobiology from computational models, describing the effect that changes associated to the mechanical environment induce in bone response, implant design and scaffold-driven bone regeneration.
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