Journal
BMC MUSCULOSKELETAL DISORDERS
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12891-021-04937-8
Keywords
Opioid; Risk factors; Total knee arthroplasty; Length of stay
Categories
Funding
- Department of Knee Injury, Luoyang Orthopedic Hospital of Henan Province
- Department of Orthopaedic surgery, West China Hospital, Sichuan University
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The study found that postoperative opioid use is common in patients undergoing primary total knee arthroplasty (TKA), with longer operative time being a significant risk factor for opioid use and the use of tranexamic acid being a protective factor. Additionally, patients in the opioid group had longer length of stay (LOS) compared to non-opioid users.
Background Characterizing the impacts of postoperative opioid use on total knee arthroplasty (TKA) patients may help optimize the pain management after TKA. The aim of the study is to examine the prevalence and risk factors for opioid use with an enhanced-recovery programme after primary TKA. Methods We identified 361 patients undergoing TKA, and separated those on the basis of whether to receive opioid use after surgery. Themultivariate logistic regression model was used to identify independent risk factors for opioid use after primary TKA. Length of stay (LOS) and postoperative complications were also recorded and compared. Results The prevalence of opioid use after primary TKA was 23.0%. The significant risk factor was the longer operative time (OR [odds ratio] = 1.017, 95% CI [confidence interval] = 1.001 to 1.032, p = 0.034) and the protective factor was the utilization of tranexamic acid(OR= 0.355, 95% CI = 0.161 to 0.780, p = 0.010). In addition, the LOS was longer in opioid group (p < 0.05). Conclusion Considering the adverse health effects of opioid use, strategies need to be developed to prevent persistent opioid use after TKA. Reducing operative time and the application of tranexamic acid could lower the risk of opioid use with an enhanced-recovery programme after primary TKA.
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