Journal
BMC INFECTIOUS DISEASES
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12879-021-06770-9
Keywords
Myobacterium marseillenese; Mycobacterium avium complex; Non-tuberculosis mycobacteria (NTM); Tenosynovitis; MALDI-TOF MS; AccuProbe
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Mycobacterium marseillense, a new species of the Mycobacterium avium complex, may be underreported in human infections due to similarities with Mycobacterium intracellulare. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) could be a rapid and reliable method for accurately identifying M. marseillese.
Background Mycobacterium marseillense is a new species of the Mycobacterium avium complex. There has been only a few human infections caused by M. marseillense worldwide. Case presentation We report a case of tenosynovitis caused by M. marseillense in an immunocompetent adult in Japan. The isolate was initially identified as M. intracellulare using commercial real time polymerase chain reaction assays and later identified as M. marseillense with sequencing of the the rpoB and hsp65 regions, and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Conclusions This is the first case reporting on M. marseillense generating a positive result with commercial real time PCR assays targeting MAC. Human infections associated by M. marseillense might be underreported due to similarities with Mycobacterium intracellulare. To accurately identify M. marseillese, MALDI-TOF MS might provide a rapid and reliable method.
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