4.6 Article

The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis stratification

Related references

Note: Only part of the references are listed.
Article Cell Biology

Comparative genomic analysis of head and body/tail of pancreatic ductal adenocarcinoma at early and late stages

Xueyou Zhang et al.

Summary: Compared to pancreatic head cancers, pancreatic body/tail cancers exhibit higher mutation rates in KRAS and SMAD4 genes. SMAD4 mutation rate is significantly higher in pancreatic body/tail cancers at early stages, while KRAS mutation rate is higher at late stages. Pancreatic body/tail cancers seem to be more malignant than pancreatic head cancers at late stages.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Oncology

Genetic aberrations in Chinese pancreatic cancer patients and their association with anatomic location and disease outcomes

Junliang Lu et al.

Summary: Pancreatic cancer patients exhibit high prevalence of driver mutations in genes like KRAS and TP53. Tumors from different parts of the pancreas show distinct mutational profiles, with specific KRAS mutations associated with better prognosis, while mutations in ARID1A and multiple driver genes predict poorer outcomes.

CANCER MEDICINE (2021)

Article Oncology

Distinct genomic profile in h. pylori-associated gastric cancer

Xiaochen Zhang et al.

Summary: Gastric cancer, a common and deadly cancer type, has four subtypes with unique molecular alterations. Helicobacter pylori-positive gastric tumors tend to be genome stable and microsatellite stable, showing a distinct genomic landscape. Deep sequencing is promising for uncovering characteristics of microbial environment in tumors.

CANCER MEDICINE (2021)

Article Medicine, Research & Experimental

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma

Lin Shui et al.

Summary: In this retrospective study, the role of germline and somatic DDR mutations in predicting the efficacy of olaparib and platinum-based chemotherapy in Chinese PDAC patients was shown. The DDR mutation was found to be an independent prognostic factor for survival analysis of advanced PDAC patients. Further investigation is needed to determine the value of DDR mutation in predicting hypermutation status and sensitivity to PD-1 blockade.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Pathology

Frequency of mismatch repair deficiency in pancreatic ductal adenocarcinoma

Soz Abdulrahman Ahmad-Nielsen et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

Meeting Abstract Oncology

A phase I/II multiple expansion cohort trial of MRTX849 in patients with advanced solid tumors with KRAS G12C mutation.

Kyriakos P. Papadopoulos et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Article Oncology

Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors

David Jeremie Birnbaum et al.

CANCERS (2019)

Article Surgery

The Impact of Tumor Location on Resection and Survival for Pancreatic Ductal Adenocarcinoma

Leah K. Winer et al.

JOURNAL OF SURGICAL RESEARCH (2019)

Review Gastroenterology & Hepatology

Pathology of pancreatic cancer

Lena Haeberle et al.

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Surgery

Defining the molecular pathology of pancreatic body and tail adenocarcinoma

S. B. Dreyer et al.

BRITISH JOURNAL OF SURGERY (2018)

Article Gastroenterology & Hepatology

IPMNs with co-occurring invasive cancers: neighbours but not always relatives

Matthaus Felsenstein et al.

Article Medicine, Research & Experimental

SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity

Youwei Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Gastroenterology & Hepatology

Hypermutation In Pancreatic Cancer

Jeremy L. Humphris et al.

GASTROENTEROLOGY (2017)

Review Oncology

Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance

Alison M. Schram et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

KrasG12D induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells

S. Diersch et al.

ONCOGENE (2016)

Article Oncology

Cancer Statistics in China, 2015

Wanqing Chen et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

Article Multidisciplinary Sciences

Genomic analyses identify molecular subtypes of pancreatic cancer

Peter Bailey et al.

NATURE (2016)

Article Gastroenterology & Hepatology

Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer

Tadafumi Asaoka et al.

PANCREATOLOGY (2016)

Review Oncology

Pancreatic cancer biology and genetics from an evolutionary perspective

Alvin Makohon-Moore et al.

NATURE REVIEWS CANCER (2016)

Article Multidisciplinary Sciences

Whole genomes redefine the mutational landscape of pancreatic cancer

Nicola Waddell et al.

NATURE (2015)

Article Multidisciplinary Sciences

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Agnieszka K. Witkiewicz et al.

NATURE COMMUNICATIONS (2015)

Article Biochemical Research Methods

FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution

Aaron M. Newman et al.

BIOINFORMATICS (2014)

Article Biochemical Research Methods

DELLY: structural variant discovery by integrated paired-end and split-read analysis

Tobias Rausch et al.

BIOINFORMATICS (2012)

Article Biochemistry & Molecular Biology

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

Daniel C. Koboldt et al.

GENOME RESEARCH (2012)

Article Biochemistry & Molecular Biology

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

Eric A. Collisson et al.

NATURE MEDICINE (2011)

Article Cell Biology

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

Jian Wu et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Biochemical Research Methods

Fast and accurate long-read alignment with Burrows-Wheeler transform

Heng Li et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Aaron McKenna et al.

GENOME RESEARCH (2010)

Article Oncology

SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer

Amanda Blackford et al.

CLINICAL CANCER RESEARCH (2009)

Article Gastroenterology & Hepatology

The anatomic location of pancreatic cancer is a prognostic factor for survival

Avo Artinyan et al.

Review Multidisciplinary Sciences

Smad-dependent and Smad-independent pathways in TGF-β family signalling

R Derynck et al.

NATURE (2003)