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Article
Oncology
TRAP1 suppresses oral squamous cell carcinoma progression by reducing oxidative phosphorylation metabolism of Cancer-associated fibroblasts
Li Xiao et al.
Summary: This study found that CAFs in oral squamous cell carcinoma exhibit greater mitochondrial activity and preferentially use oxidative phosphorylation for glucose metabolism. TRAP1 was identified as an important regulatory molecule in CAFs, promoting OSCC progression by regulating OXPHOS.
BMC CANCER (2021)
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