Journal
BMC CANCER
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12885-021-09054-2
Keywords
Gut microbiome; Colorectal cancer; Prognostic and predictive biomarkers; Modulation of gut microbiome; Systemic treatment of CRC
Categories
Funding
- Slovenian Research Agency (ARRS) [P3-0321]
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Colorectal cancer is still common worldwide, and the gut microbiome plays a key role in its development. Understanding the composition of bacterial strains influenced by various factors is crucial for screening, early detection, and predicting treatment outcomes. Microbiome modulation is a promising strategy in medicine to improve health outcomes.
Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies. The composition of bacterial strains and the influence of geography, race, sex, and diet on the composition of the microbiome serve as important information for screening, early detection and prediction of the treatment outcome of CRC. Microbiome modulation is one of the most prospective new strategies in medicine to improve the health of individuals. Therefore, future research and clinical trials on the gut microbiome in oncology as well as in the treatment of CRC patients are warranted to determine the efficacy of systemic treatments for CRC, minimize adverse effects and increase survival rates.
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