BRAFV600E vs cell of origin: what governs LCH?

In this issue of Blood, Shi et al use immunophenotyping and single-cell RNA sequencing to identify differentially expressed genes (DEGs) in various populations of circulatingmononuclear cells frompediatric patientswith Langerhans cell histiocytosis (LCH).

Automated summary

The study utilized immunophenotyping and single-cell RNA sequencing to identify differentially expressed genes in various populations of circulating mononuclear cells from pediatric patients with Langerhans cell histiocytosis (LCH), providing crucial insights into the pathogenesis of LCH.