Old drug revisited disulfiram, NETs, and sepsis

In this issue of Blood, Silva et al demonstrate that disulfiram inhibits gasdermin D (GSDMD) and thereby inhibits the excessive formation of neutrophil extracellular traps (NETs) by neutrophilic granulocytes during sepsis.(1)

Automated summary

The study demonstrates that disulfiram inhibits the excessive formation of neutrophil extracellular traps during sepsis by targeting gasdermin D.