Blood will tell: profiling Sezary syndrome

Article Dermatology

The immunopathogenesis and immunotherapy of cutaneous T cell lymphoma: Pathways and targets for immune restoration and tumor eradication

Joseph S. Durgin et al.

Summary: CTCLs are malignancies of skin-trafficking T cells, with patients experiencing immune dysfunction and susceptibility to infections. Therapies stimulating immunity show superior outcomes compared to conventional chemotherapy. Recent research has identified potential therapeutic targets by better understanding the pathogenesis of immune deficits in CTCL patients.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Review Dermatology

The importance of assessing blood tumour burden in cutaneous T-cell lymphoma

M. H. Vermeer et al.

Summary: Mycosis fungoides (MF) and Sezary syndrome (SS) are well-studied subtypes of cutaneous T-cell lymphoma. Accurate quantification of blood involvement is crucial for diagnosis, staging, prognosis, and treatment response assessment. Flow cytometry-based classifications are being developed to improve the assessment of blood involvement and treatment response in MF and SS.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Immunology

Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells

Katharina Rindler et al.

Summary: Mycosis fungoides is the most common primary cutaneous T-cell lymphoma, and little is known about the phenotypic and functional properties of malignant T cells in different tissue environments. The study found that malignant T cells exhibit different phenotypes, which may explain the multi-focal nature of the disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Hematology

Improved Sezary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sezary syndrome

Safa Najidh et al.

Summary: The study conducted immunophenotypic profiling of Sezary syndrome patients and found diverse phenotypes and different maturation states of Sezary cells. They also identified downregulated genes at the RNA level that can discriminate Sezary cells from normal CD4(+) T cells.

BLOOD (2021)

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Letter Dermatology