4.7 Article

Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia

Related references

Note: Only part of the references are listed.
Article Hematology

Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Eμ-TCL1 mice

Bola S. Hanna et al.

Summary: Ibrutinib, as a BTK inhibitor, not only affects CLL cells by blocking B-cell receptor signaling, but also impacts the microenvironment and CD8(+) T cells. Direct effects on TCR activity and the potential for co-stimulation via CD28 to overcome these effects have been demonstrated in studies. Additionally, combination therapy with PD-1/PD-L1 blockade shows promise in improving CD8(+) T-cell function in CLL.

HAEMATOLOGICA (2021)

Article Oncology

Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients

Fuli Fan et al.

Summary: The use of ibrutinib has been shown to improve the viability and expansion of CART cells derived from CLL patients, enriching them with less-differentiated naive-like T cell subsets and reducing exhaustion marker expression. Additionally, ibrutinib enhances the cytokine release capacity of CLL patient-derived CART cells, suggesting it can improve the yield and function of these cell products.

INTERNATIONAL JOURNAL OF CANCER (2021)

Review Biochemistry & Molecular Biology

Harnessing the Effects of BTKi on T Cells for Effective Immunotherapy against CLL

Maissa Mhibik et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Hematology

T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?

Philipp M. Roessner et al.

LEUKEMIA (2020)

Review Medicine, General & Internal

Treatment of Chronic Lymphocytic Leukemia

Jan A. Burger

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Ibrutinib and Venetoclax for First-Line Treatment of CLL

Nitin Jain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Hematology

Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment

Michael Hallek

AMERICAN JOURNAL OF HEMATOLOGY (2019)

Article Hematology

Resistance mechanism for ibrutinib in marginal zone lymphoma

Narendranath Epperla et al.

BLOOD ADVANCES (2019)

Review Hematology

From Biology to Therapy: The CLL Success Story

Deyan Y. Yosifov et al.

HEMASPHERE (2019)

Article Medicine, Research & Experimental

Ibrutinib treatment improves T cell number and function in CLL patients

Meixiao Long et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Multidisciplinary Sciences

Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

Idit Sagiv-Barfi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Medicine, General & Internal

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

Jennifer A. Woyach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Letter Medicine, General & Internal

Ibrutinib Resistance in Chronic Lymphocytic Leukemia

Richard R. Furman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia

J. C. Byrd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

John C. Byrd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

Marcus Duehren-von Minden et al.

NATURE (2012)

Article Hematology

B-cell receptor signaling in chronic lymphocytic leukemia

Freda K. Stevenson et al.

BLOOD (2011)

Article Multidisciplinary Sciences

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Lee A. Honigberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)