Journal
BIPOLAR DISORDERS
Volume 24, Issue 4, Pages 400-411Publisher
WILEY
DOI: 10.1111/bdi.13139
Keywords
functional connectivity (FC); functional homotopy (FH); interhemispheric function integration; major depressive disorder (MDD); resting-state functional magnetic resonance imaging (R-fMRI); voxel-mirrored homotopic connectivity (VMHC)
Categories
Funding
- National Natural Science Foundation of China [82060259, 81760296, 81660237]
- Medical Leader Foundation of Yunnan Province [L2019011, L2019004]
- Famous Doctors Project of Yunnan Province Plan [YNWR-MY-2018-040, YNWR-MY-2018-041]
- Applied Basic Key Project of Yunnan Provincial Department of Science and Technology--Kunming Medical University Joint Foundation [2017FE468(-176)]
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Based on a large sample analysis of brain imaging data, we found that patients with Major Depressive Disorder (MDD) exhibit reduced homotopic connectivity, particularly in the posterior cingulate gyrus/precuneus (PCC/PCu) region. Furthermore, this reduction is influenced by gender, age, episode type, and illness severity. These findings suggest a tendency for disrupted information exchange between hemispheres in the depressed brain.
Background Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < 0.002, z = -7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction in MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
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