Journal
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Volume 69, Issue 5, Pages 2017-2027Publisher
WILEY
DOI: 10.1002/bab.2264
Keywords
1H-pyrazolo[1; 2-b]phthalazine-5; 10-dione; Aspergillus niger; lipase
Funding
- University Grants Commission, New Delhi, India
Ask authors/readers for more resources
A novel method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via lipase from Aspergillus niger-catalyzed multicomponent reaction has been reported. The method shows high efficiency, environmental friendliness, simple workup procedure, and good yield (70-86%). It has the potential to replace traditional chemical synthesis routes for nitrogen-containing heterocyclic compounds.
A new method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via lipase from the Aspergillus niger-catalyzed multicomponent reaction of aldehydes, malononitrile, and phthalhydrazide is reported herein for the first time. This novel method holds several advantages, including its efficiency, environmental friendliness, simple workup procedure, and good yield (70-86%). The effects of temperature, organic solvents, and water content were investigated. This protocol has the potential to replace traditional chemical synthesis routes for the synthesis of nitrogen-containing heterocyclic compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available