Journal
BIOSCIENCE REPORTS
Volume 42, Issue 1, Pages -Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20212510
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Funding
- Natural Science Foundation of Hubei Province [2019CFB591]
- Bureau of Science and Technology of Jingzhou Municipality [2020CB21-35]
- Joint Development Fund for Medical Research of Yangtze University [WJ2019-13]
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This review summarizes the major functions and mechanisms of action of circRNAs in stem cell biology and disease progression. It highlights the common pathways mediated by circRNAs in different types of stem cells and discusses their diagnostic significance in stem cell-based therapy.
Circular RNAs (circRNAs) are a special class of endogenous RNAs with a wide variety of pathophysiological functions via diverse mechanisms, including transcription, microRNA (miRNA) sponge, protein sponge/decoy, and translation. Stem cells are pluripotent cells with unique properties of self-renewal and differentiation. Dysregulated circRNAs identi-fied in various stem cell types can affect stem cell self-renewal and differentiation potential by manipulating stemness. However, the emerging roles of circRNAs in stem cells remain largely unknown. This review summarizes the major functions and mechanisms of action of circRNAs in stem cell biology and disease progression. We also highlight circRNA-mediated common pathways in diverse stem cell types and discuss their diagnostic significance with respect to stem cell-based therapy.
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