Journal
BIORESOURCE TECHNOLOGY
Volume 341, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2021.125781
Keywords
Bacterial cellulose; Cheap carbon source; Scale-up; Productivity; Industrialisation
Funding
- Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project [TSBICIP-KJGG-015-04]
- National Natural Science Foundation of China [U2003128]
- National Key Research and Development Program of China [2020YFC1808600]
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The combination of strain stabilization, optimization of culture conditions, and the use of a cheap carbon source in 20 L containers has enabled highly efficient, low-cost, large-scale BC production. The optimization of culture conditions significantly increased both BC productivity and sugar conversion ratio, promoting the industrialization of BC production.
Bacterial cellulose (BC) has a huge global market due to its excellent properties and wide range of applications. However, due to high production costs, low productivity, and unsatisfactory scale-up production, industrialisation has been slow. Herein, stabilization of strain, optimisation of culture conditions, and a cheap carbon source were combined to achieve highly efficient, low-cost, large-scale BC production in 20 L containers. Optimisation of culture conditions increased both BC productivity and sugar conversion ratio significantly, from 2.08 g/L/day and 9.78% to 17.13 g/L/day and 70.31%, respectively. Furthermore, BC productivity and sugar conversion ratio reached 13.96 g/L/day and 85.50% using corn stover total hydrolysate as carbon source. The low-cost, facile, and highly efficient process can generate large quantities of BC, and could promote industrialisation of BC production.
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