Related references
Note: Only part of the references are listed.Structural insights into the inhibition of glycine reuptake
Azadeh Shahsavar et al.
NATURE (2021)
Illumination of serotonin transporter mechanism and role of the allosteric site
Dongxue Yang et al.
SCIENCE ADVANCES (2021)
Investigating the Mechanism of Sodium Binding to SERT Using Direct Simulations
Daniel Szollosi et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
Per Plenge et al.
NATURE COMMUNICATIONS (2021)
Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport
Jonathan A. Coleman et al.
NATURE (2019)
Conformational dynamics of the human serotonin transporter during substrate and drug binding
Ingvar R. Moller et al.
NATURE COMMUNICATIONS (2019)
Monoamine transporters: structure, intrinsic dynamics and allosteric regulation
Mary Hongying Cheng et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
A structural model of the human serotonin transporter in an outward-occluded state
Eva Hellsberg et al.
PLOS ONE (2019)
Substrate-induced conformational dynamics of the dopamine transporter
Anne Kathrine Nielsen et al.
NATURE COMMUNICATIONS (2019)
Serotonin transport in the 21st century
Gary Rudnick et al.
JOURNAL OF GENERAL PHYSIOLOGY (2019)
Quantitative Assessment of the Energetics of Dopamine Translocation by Human Dopamine Transporter
Mary Hongying Cheng et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2018)
Improvements to the APBS biomolecular solvation software suite
Elizabeth Jurrus et al.
PROTEIN SCIENCE (2018)
What Contributes to Serotonin-Norepinephrine Reuptake Inhibitors' Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation
Weiwei Xue et al.
ACS CHEMICAL NEUROSCIENCE (2018)
Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter
Louise Laursen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Structural basis for recognition of diverse antidepressants by the human serotonin transporter
Jonathan A. Coleman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
Daniel S. Terry et al.
NATURE COMMUNICATIONS (2018)
Structural basis for recognition of diverse antidepressants by the human serotonin transporter
Jonathan A. Coleman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition
Xavier Periole et al.
SCIENTIFIC REPORTS (2018)
A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition
Talia Zeppelin et al.
PLOS COMPUTATIONAL BIOLOGY (2018)
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT
Patrick S. Merkle et al.
SCIENCE ADVANCES (2018)
Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT
Yuan-Wei Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Modification of a Putative Third Sodium Site in the Glycine Transporter GlyT2 Influences the Chloride Dependence of Substrate Transport
Cristina Benito-Munoz et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Free Energy Landscape of the Complete Transport Cycle in a Key Bacterial Transporter
Balaji Selvam et al.
ACS CENTRAL SCIENCE (2018)
Crystal structure of the bacterial acetate transporter SatP reveals that it forms a hexameric channel
Pengcheng Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state
Sebastian Stolzenberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter
Carina Kern et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Conformational dynamics of a neurotransmitter: sodium symporter in a lipid bilayer
Suraj Adhikary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter
Andreas Anderluh et al.
NATURE COMMUNICATIONS (2017)
A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter
Asghar M. Razavi et al.
SCIENTIFIC REPORTS (2017)
Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter
Peter S. Hasenhuetl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
X-ray structures and mechanism of the human serotonin transporter
Jonathan A. Coleman et al.
NATURE (2016)
Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2
Nandhitha Subramanian et al.
PLOS ONE (2016)
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
Christian B. Billesbolle et al.
NATURE COMMUNICATIONS (2016)
Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus
George Khelashvili et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Structural Symmetry in Membrane Proteins
Lucy R. Forrest
ANNUAL REVIEW OF BIOPHYSICS, VOL 44 (2015)
MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories
Robert T. McGibbon et al.
BIOPHYSICAL JOURNAL (2015)
Mechanisms of Anion Conduction by Coupled Glutamate Transporters
Jan-Philipp Machtens et al.
CELL (2015)
A Dualistic Conformational Response to Substrate Binding in the Human Serotonin Transporter Reveals a High Affinity State for Serotonin
Henriette Bjerregaard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Energy landscape of LeuT from molecular simulations
Mert Gur et al.
JOURNAL OF CHEMICAL PHYSICS (2015)
Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
Chad W. Hopkins et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
James A. Maier et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
PyEMMA 2: A Software Package for Estimation, Validation, and Analysis of Markov Models
Martin K. Scherer et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Neurotransmitter and psychostimulant recognition by the dopamine transporter
Kevin H. Wang et al.
NATURE (2015)
Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter
Mary Hongying Cheng et al.
STRUCTURE (2015)
Designing modulators of monoamine transporters using virtual screening techniques
Ole V. Mortensen et al.
FRONTIERS IN PHARMACOLOGY (2015)
Structure and Regulatory Interactions of the Cytoplasmic Terminal Domains of Serotonin Transporter
Cristina Fenollar-Ferrer et al.
BIOCHEMISTRY (2014)
Electrical coupling between the human serotonin transporter and voltage-gated Ca2+ channels
Iwona Ruchala et al.
CELL CALCIUM (2014)
The Two Na+ Sites in the Human Serotonin Transporter Play Distinct Roles in the Ion Coupling and Electrogenicity of Transport
Bruce Felts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane
Andreas Anderluh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein
Peter J. Hamilton et al.
NATURE CHEMICAL BIOLOGY (2014)
Conformational dynamics of ligand-dependent alternating access in LeuT
Kelli Kazmier et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters
Lina Malinauskaite et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1
Kelli Kazmier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Complete Mapping of Substrate Translocation Highlights the Role of LeuT N-terminal Segment in Regulating Transport Cycle
Mary Hongying Cheng et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine (Prozac)
Jacob Andersen et al.
MOLECULAR PHARMACOLOGY (2014)
Coupled Global and Local Changes Direct Substrate Translocation by Neurotransmitter-Sodium Symporter Ortholog LeuT
Mary Hongying Cheng et al.
BIOPHYSICAL JOURNAL (2013)
SPFP: Speed without compromise-A mixed precision model for GPU accelerated molecular dynamics simulations
Scott Le Grand et al.
COMPUTER PHYSICS COMMUNICATIONS (2013)
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
Daniel R. Roe et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
Romelia Salomon-Ferrer et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)
Structural basis for action by diverse antidepressants on biogenic amine transporters
Hui Wang et al.
NATURE (2013)
X-ray structure of dopamine transporter elucidates antidepressant mechanism
Aravind Penmatsa et al.
NATURE (2013)
Transient formation of water-conducting states in membrane transporters
Jing Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Neurotransmitter Transporters: Structure Meets Function
Paul J. Focke et al.
STRUCTURE (2013)
Interaction of Antidepressants with the Serotonin and Norepinephrine Transporters MUTATIONAL STUDIES OF THE S1 SUBSTRATE BINDING POCKET
Lena Sorensen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born
Andreas W. Goetz et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations
Mari Gabrielsen et al.
JOURNAL OF MOLECULAR MODELING (2012)
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
Harini Krishnamurthy et al.
NATURE (2012)
Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP
Kamil Khafizov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport
L. Keith Henry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Markov models of molecular kinetics: Generation and validation
Jan-Hendrik Prinz et al.
JOURNAL OF CHEMICAL PHYSICS (2011)
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions
Mats H. M. Olsson et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue
Yongfang Zhao et al.
NATURE (2011)
Crystal structure of a potassium ion transporter, TrkH
Yu Cao et al.
NATURE (2011)
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
Avner Schlessinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters
Jacob Andersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na+ Ion Release
Heidi Koldso et al.
PLOS COMPUTATIONAL BIOLOGY (2011)
Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter
Jacob Andersen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Enhanced Modeling via Network Theory: Adaptive Sampling of Markov State Models
Gregory R. Bowman et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2010)
The Two Enantiomers of Citalopram Bind to the Human Serotonin Transporter in Reversed Orientations
Heidi Koldso et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
Yongfang Zhao et al.
NATURE (2010)
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter: sodium symporters
Derek P. Claxton et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
SYNTAXIN 1A REGULATES DOPAMINE TRANSPORTER ACTIVITY, PHOSPHORYLATION AND SURFACE EXPRESSION
M. A. Cervinski et al.
NEUROSCIENCE (2010)
Modeling and Dynamics of the Inward-Facing State of a Na+/Cl- Dependent Neurotransmitter Transporter Homologue
Saher Afshan Shaikh et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
The Expanded Biology of Serotonin
Miles Berger et al.
ANNUAL REVIEW OF MEDICINE (2009)
An intracellular interaction network regulates conformational transitions in the dopamine transporter
Julie Kniazeff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM
Sunhwan Jo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation
Leyla Celik et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
The mechanism of a neurotransmitter:sodium symporter -: Inward release of Na+ and substrate is triggered by substrate in a second binding site
Lei Shi et al.
MOLECULAR CELL (2008)
The binding sites for cocaine and dopamine in the dopamine transporter overlap
Thijs Beuming et al.
NATURE NEUROSCIENCE (2008)
Mechanism for alternating access in neurotransmitter transporters
Lucy R. Forrest et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Identification of a chloride ion binding site in Na+/Cl--dependent transporters
Lucy R. Forrest et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Monitoring the function of membrane transport proteins in detergent-solubilized form
Matthias Quick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The cytoplasmic substrate permeation pathway of serotonin transporter
Yuan-Wei Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Bio3d: an R package for the comparative analysis of protein structures
Barry J. Grant et al.
BIOINFORMATICS (2006)
State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum
Matthias Quick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
5-hydroxytryptamine in the cardiovascular system: Focus on the serotonin transporter (sert)
Wei Ni et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)
Neurotransmitter transporters: molecular function of important drug targets
Ulrik Gether et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle
VM Korkhov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding
N Sen et al.
NEUROPHARMACOLOGY (2005)
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
A Yamashita et al.
NATURE (2005)
Serotonin transporter: Gene, genetic disorders, and pharmacogenetics
DL Murphy et al.
MOLECULAR INTERVENTIONS (2004)
Regulating the conducting states of a mammalian serotonin transporter
MW Quick
NEURON (2003)
Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter
S Sucic et al.
JOURNAL OF NEUROCHEMISTRY (2002)
The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis
NH Chen et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A
SL Deken et al.
NATURE NEUROSCIENCE (2000)
Permeation and gating residues in serotonin transporter
JG Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Share Paper
