Journal
BIOORGANIC CHEMISTRY
Volume 116, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2021.105391
Keywords
Coumarin; Fluorescent; Biosensor; Imaging; Diagnosis
Funding
- National Natural Science Foundation of China [81973269, U1704135]
- Program for Innovative Research Team of Science and Technology in the University of Henan Province [21IRTSTHN005]
- Henan Scientific Research Fund for Returned Scholars
- 510 talent programs (Jiangsu, China)
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Novel fluorescent probe based on piperazine-coumarin scaffold with enhanced brightness and solubility was successfully developed for efficient detection of bio-thiols. There is great potential for clinical applications in distinguishing pathological tissue from normal tissue.
The development of novel fluorescent dyes for bio-thiol is of great importance in biological, clinical and pharmaceutical sciences. Given the importance of bio-thiol anticipating in numerous physiological processes, there is a great need to construct fluorescent biosensors with high quality to detect them. Fluorophores, especially those used in bio-system, usually require high-quality properties such as high brightness, good water solubility, biocompatible and photostability. Herein, we reported a novel fluorescent probe based on piperazine-coumarin scaffold with enhanced brightness and solubility. To further demonstrate the potential clinical applications, we performed living cell fluorescence image and human esophageal carcinoma diagnosis. The result indicated that we were able to distinguish pathological tissue from normal tissue by applying this probe. Thus, we hope this design will be helpful to develop high-quality fluorophores for clinical diagnosis.
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