Related references
Note: Only part of the references are listed.SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
Wioletta Rut et al.
NATURE CHEMICAL BIOLOGY (2021)
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors
Julian Breidenbach et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2
Chih-Jung Kuo et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)
SARS-CoV-2 variants and ending the COVID-19 pandemic
Arnaud Fontanet et al.
LANCET (2021)
SARS-CoV-2 M-pro inhibitors with antiviral activity in a transgenic mouse model
Jingxin Qiao et al.
SCIENCE (2021)
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
Kas Steuten et al.
ACS INFECTIOUS DISEASES (2021)
A cyclic peptide inhibitor of the SARS-CoV-2 main protease
Adam G. Kreutzer et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease
Nitin A. Patil et al.
ACS MEDICINAL CHEMISTRY LETTERS (2021)
Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection
Koen Vandyck et al.
CURRENT OPINION IN VIROLOGY (2021)
A biocompatible stapling reaction for in situ generation of constrained peptides
Richard Morewood et al.
CHEMICAL SCIENCE (2021)
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
Aiping Wu et al.
CELL HOST & MICROBE (2020)
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
Linlin Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
An interactive web-based dashboard to track COVID-19 in real time
Ensheng Dong et al.
LANCET INFECTIOUS DISEASES (2020)
COVID-19 Drug Discovery Using Intensive Approaches
Ayumu Asai et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Wenhao Dai et al.
SCIENCE (2020)
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang et al.
SCIENCE (2020)
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin et al.
NATURE (2020)
Structure-Based Macrocyclization of Substrate Analogue NS2B-NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses
Niklas J. Braun et al.
CHEMMEDCHEM (2020)
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
Chunlong Ma et al.
CELL RESEARCH (2020)
The SARS-CoV-2 main protease as drug target
Sven Ullrich et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors
Chunlong Ma et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)
Biocompatible Macrocyclization between Cysteine and 2-Cyanopyridine Generates Stable Peptide Inhibitors
Christoph Nitsche et al.
ORGANIC LETTERS (2019)
Proteases and protease inhibitors in infectious diseases
Ayodeji A. Agbowuro et al.
MEDICINAL RESEARCH REVIEWS (2018)
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
Anushka C. Galasiti Kankanamalage et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Development of Small-Molecule MERS-CoV Inhibitors
Ruiying Liang et al.
VIRUSES-BASEL (2018)
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
Vathan Kumar et al.
ANTIVIRAL RESEARCH (2017)
A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets
Toby Passioura et al.
CHEMICAL COMMUNICATIONS (2017)
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
Thanigaimalai Pillaiyar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
Yunjeong Kim et al.
PLOS PATHOGENS (2016)
A script to highlight hydrophobicity and charge on protein surfaces
Dominique Hagemans et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2015)
From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
Rolf Hilgenfeld
FEBS JOURNAL (2014)
Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease
Yutong Jiang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Mark E. Flanagan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
Rolf Hilgenfeld et al.
ANTIVIRAL RESEARCH (2013)
The newly emerged SARS-Like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease
Zhilin Ren et al.
PROTEIN & CELL (2013)
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
Lili Zhu et al.
ANTIVIRAL RESEARCH (2011)
Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors
Kenichi Akaji et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus
Ann D. Kwong et al.
NATURE BIOTECHNOLOGY (2011)
The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling
Jianing Li et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2011)
Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease
Peter W. White et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Challenges in modern drug discovery: A case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection
F. George Njoroge et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant
Kenichi Akaji et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Structure-based design,synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors
Arun K. Ghosh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Crystal structures reveal an induced-fit binding of a substrate-like aza-peptide epoxide to SARS coronavirus main peptidase
Ting-Wai Lee et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors
Magne O. Sydnes et al.
TETRAHEDRON (2006)
Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor
Syaulan Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Design and synthesis of dipeptidyl glutaminyl fluoromethyl ketones as potent severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors
HZ Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Screening of electrophilic compounds yields an aziridin, as new active-site directed SARS-CoV main protease inhibitor
E Martina et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors
AK Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Design of wide-spectrum inhibitors targeting coronavirus main proteases
HT Yang et al.
PLOS BIOLOGY (2005)
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
JJ Shie et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Mechanisms and enzymes involved in SARS coronavirus genome expression
V Thiel et al.
JOURNAL OF GENERAL VIROLOGY (2003)
Share Paper
