Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 54, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2021.116560
Keywords
Alkaloid; Natural product; Azocine; Azocane
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This review discusses the structure and bioactivity of alkaloids that contain an eight-membered N-heterocycle, and their sources of origin.
Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered Nheterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate.
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