4.7 Article

Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor γ partial agonist

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARγ and Nrf2 signaling, and abrogation of the inflammatory responses

Samir A. Salama et al.

Summary: The study demonstrated that galangin has a significant protective effect against iron-induced hepatotoxicity, reducing liver iron content, serum ferritin level, and oxidative stress. Galangin exerts its effects through various mechanisms, including up-regulation of Nrf2, PPAR gamma, and down-regulation of NF-cB signaling pathways.

LIFE SCIENCES (2021)

Editorial Material Endocrinology & Metabolism

Adiponectin and leptin in the diagnosis and therapy of NAFLD

Chrysoula Boutari et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

Article Biochemistry & Molecular Biology

Mechanistic investigation of PPARγ-facilitated anti-asthmatic effects of Galangin (Norizalpinin): Insights from in silico and in vivo analyses

Linda Jeeva Kumari Henry et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators

Yujia Han et al.

BIOMOLECULES & THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore

Sungjin Ahn et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Quantitative structural assessment of graded receptor agonism

Jinsai Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Endocrinology & Metabolism

Obesity and cancer risk: Emerging biological mechanisms and perspectives

Konstantinos Avgerinos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

Article Physiology

Adiponectin Regulation and Function

Han Fang et al.

COMPREHENSIVE PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

Laura M. van Marrewijk et al.

ACS CHEMICAL BIOLOGY (2016)

Article Chemistry, Medicinal

Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage

Santiago Garcia-Vallve et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Pharmacology & Pharmacy

Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ

Xin Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

Article Pharmacology & Pharmacy

Defining and characterizing drug/compound function

Terry Kenakin et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Article Chemistry, Multidisciplinary

17β-Estradiol inhibition of PPARγ-induced adipogenesis and adipocyte-specific gene expression

Sunhyo Jeong et al.

ACTA PHARMACOLOGICA SINICA (2011)

Review Chemistry, Multidisciplinary

PPARs and Lipid Ligands in Inflammation and Metabolism

Gregory S. Harmon et al.

CHEMICAL REVIEWS (2011)

Review Biochemistry & Molecular Biology

Brown vs white adipocytes: The PPARγ coregulator story

Arjen Koppen et al.

FEBS LETTERS (2010)

Article Endocrinology & Metabolism

The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses

J. Hoppmann et al.

JOURNAL OF ENDOCRINOLOGY (2010)

Article Gastroenterology & Hepatology

Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model

Yoshihiro Kamada et al.

JOURNAL OF HEPATOLOGY (2007)

Article Biochemistry & Molecular Biology

Partial agonists activate PPARγ using a helix 12 independent mechanism

John B. Bruning et al.

STRUCTURE (2007)

Review Biochemistry & Molecular Biology

Safety issues and prospects for future generations of PPAR modulators

Anne Rubenstrunk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

Review Cell Biology

Adipocyte differentiation from the inside out

Evan D. Rosen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Review Medicine, Research & Experimental

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Takashi Kadowaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Review Endocrinology & Metabolism

Nuclear hormone receptor coregulator: Role in hormone action, metabolism, growth, and development

MA Mahajan et al.

ENDOCRINE REVIEWS (2005)

Review Biochemistry & Molecular Biology

The mammalian Mediator complex and its role in transcriptional regulation

RC Conaway et al.

TRENDS IN BIOCHEMICAL SCIENCES (2005)

Article Endocrinology & Metabolism

Adiponectin: action, regulation and association to insulin sensitivity

AS Lihn et al.

OBESITY REVIEWS (2005)

Article Endocrinology & Metabolism

Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis

ZC Dang et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2002)

Article Biochemistry & Molecular Biology

Cloning and characterization of RAP250, a novel nuclear receptor coactivator

F Caira et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)