Dopamine, a co-regulatory component, bridges the central nervous system and the immune system

Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining physiological function in human body. In the past, most studies focused on the relationship between the dopaminergic system and neurological-related diseases. However, it has been found recently that DA is an immunomodulatory mediator and many immune cells express dopamine receptors (DRs). Some immune cells can synthesize and secrete DA and then participate in regulating immune function. DRs agonists or antagonists can improve the dysfunction of immune system through classical G protein signaling pathways or other non-receptor-dependent pathways. This article will discuss the relationship between the dopaminergic system and the immune system. It will also review the use of DRs agonists or antagonists to treat chronic and acute inflammatory diseases and corresponding immunomodulatory mechanisms.

Automated summary

Dopamine is a crucial neurotransmitter that not only plays a role in maintaining physiological function and neurological diseases, but also acts as an immunomodulatory mediator. Immune cells express dopamine receptors, synthesize and secrete dopamine to regulate immune function. dopamine receptors agonists or antagonists can improve immune system dysfunction through various signaling pathways.