Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 143, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112232
Keywords
Aptamer; SELEX; Screening method; Nucleic acid drug; Clinical trials
Funding
- Key R&D projects of Hebei Province, China [20372702D]
- Natural Science Foundation of Hebei Province, China [H2019201455, H2020201018]
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Aptamers are single stranded oligonucleotides with specific recognition and binding ability to target molecules. They have advantages of low molecular weight, easy modification and high stability. Aptamers play important roles in promoting food safety, monitoring the environment, basic research, and have great potential in clinical diagnosis and therapeutic drugs.
Aptamers are single stranded oligonucleotides with specific recognition and binding ability to target molecules, which can be obtained by Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Aptamers have the advantages of low molecular weight, low immunogenicity, easy modification and high stability. They play promising role in promoting food safety, monitoring the environment and basic research, especially in clinical diagnosis and therapeutic drugs. To date, great achievements regarding the selection, modifications and application of aptamers have been made. However, since it is still a challenge to obtain aptamers with high affinity in a more effective way, few aptamer-based products have already successfully entered into clinical use. This review aims to provide a thorough overview of the latest advances in this rapidly developing field, focusing on aptamer screening methods for different targets, the structure of the interaction between aptamers and target substances, and the challenges and potential of current therapeutic aptamers.
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