Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 142, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112074
Keywords
Heat shock proteins (HSPs); Cancer diagnosis and prognosis; Biomarker; Cancer metabolism; HSP inhibitors; HSP-based immunotherapies
Funding
- Drug Innovation Major Project of China [2018ZX09711-001-009]
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This review summarizes the significant roles of heat shock proteins in cancer diagnosis, metabolism regulation, and therapeutic targeting, highlighting the importance of research and future directions in this field.
Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics.
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