Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 142, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111958
Keywords
Phloroglucinol; Advanced glycation end products; Oxidative stress; Protein glycation; Protein oxidation
Funding
- National Science Centre, Poland [2018/31/N/NZ7/03242]
- Polish Ministry of Science and Higher Education program Strategy of Excel-lence-the University of Research in the years 2018-2019 [0017/SDU/2018/18]
- Medical University of Bialystok, Poland [SUB/1/DN/20/003/4406, SUB/1/DN/20/002/1209, SUB/1/DN/20/002/3330]
- Foundation for Polish Science (FNP)
- Medical University of Bialystok, Poland
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The study found that phloroglucinol has strong and broad anti-glycation and anti-oxidative effects, making it a potential adjunct therapy for diabetes.
ABSTR A C T The treatment of diabetes mellitus aftermaths became one of medicine's most significant therapeutical and financial issues in the XXI century. Most of which are related to protein glycation and oxidative stress caused by long lasting periods of hyperglycemia. Thus, even within a venerable one, searching for new drugs, displaying anti-glycation and anti-oxidative properties seem useful as an additive therapy of diabetes. In this paper, we assessed the anti-glycating properties of phloroglucinol, a drug discovered in the XIX century and still used in many countries for its antispasmodic action. Herewith, we present its effect on protein glycation, glycoxidation, and oxidative damage in an albumin glycation/oxidation model and HepG2 cells treated with high glucose concentrations. The phloroglucinol showed the strongest and the widest protective effect within all analyzed antiglycating (aminoguanidine, pioglitazone) and anti-oxidative (vitamin C, GSH) agents. To the very best of our knowledge, this is the first study showing the properties of phloroglucinol in vitro what once is proven in other models might deepen its clinical applications.
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